Pietro A. Canetta, MD
Assistant Professor of Medicine
Education & Training
- Longitudinal Outcomes of COVID-19-Associated Collapsing Glomerulopathy and Other Podocytopathies October 21, 2021CONCLUSIONS: Half of 14 patients with COVID-19-associated collapsing glomerulopathy requiring dialysis achieved dialysis independence, but the long-term prognosis of residual proteinuric CKD remains guarded, indicating a need for more effective therapy.
- Polyuria due to Pressure Natriuresis in Venoarterial Extracorporeal Membrane Oxygenation October 1, 2021We report a case of a 40-year-old woman who developed profound polyuria (>25 L urine output) immediately after initiation of venoarterial (VA) extracorporeal membrane oxygenation (ECMO). Investigations into the cause determined the polyuria was due to marked natriuresis (>85 g of sodium excreted in 1 day). This natriuresis persisted despite low cardiac filling pressures and […]
- Diagnostic Approach to Glomerulonephritis With Fibrillar IgG Deposits and Light Chain Restriction April 29, 2021CONCLUSION: A systematic diagnostic approach with ancillary techniques is essential for proper classification and assignment of monoclonal gammopathy of renal significance status in cases of GN with fibrillary IgG deposits and light chain restriction by IF-F.
- Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine April 15, 2021Hydralazine, a widely used therapy for hypertension and heart failure, can elicit autoimmune disease, including anti-neutrophil cytoplasmic antibody associated glomerulonephritis (ANCA-GN). We identified 80 cases of ANCA-GN complicating treatment with hydralazine, accounting for 4.3% (80/1858 biopsies) of ANCA-GN diagnosed between 2006 and 2019. Over three-fourths of patients were on hydralazine for at least one year, […]
- Concurrent Anti-Glomerular Basement Membrane Antibody Disease and Membranous Nephropathy: A Case Series January 9, 2021CONCLUSIONS: In this case series, the presentation of concurrent anti-GBM disease and MN was characterized by rapidly progressive glomerulonephritis and poor kidney outcomes. These findings suggest possible value from earlier diagnosis and the need for identification of more effective treatment regimens.
- Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study October 26, 2020CONCLUSION: HRQOL measures were responsive to changes in disease activity, as indicated by edema. HRQOL over time was not predicted by laboratory-based markers of disease. Patient-reported edema and number of symptoms were the strongest predictors of HRQOL, highlighting the importance of the patient experience in glomerular disease. HRQOL outcomes inform understanding of the patient experience […]
- Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications October 16, 2020CONCLUSIONS: Although the native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Albeit rare, death can occur postbiopsy. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI.
- Kidney Biopsy Findings in Patients with COVID-19 July 19, 2020CONCLUSIONS: Patients with COVID-19 develop a wide spectrum of glomerular and tubular diseases. Our findings provide evidence against direct viral infection of the kidneys as the major pathomechanism for COVID-19-related kidney injury and implicate cytokine-mediated effects and heightened adaptive immune responses.
- The clinicopathologic spectrum of segmental membranous glomerulopathy June 30, 2020Membranous glomerulopathy (MGN) is characterized by global subepithelial immune deposits that stain most intensely by immunofluorescence for IgG. Here we describe the clinical and pathologic findings in a cohort of patients with MGN in which, by definition, only segmental immune deposits are present. This rare variant, termed segmental MGN (sMGN), is poorly characterized. We retrospectively […]
- Persistent Disease Activity in Patients With Long-Standing Glomerular Disease June 11, 2020CONCLUSION: Disease activity did not differ among patients with shorter versus longer duration of disease. Such survivor patients, with long-term but persistent disease, are potentially highly informative for understanding the clinical course and pathogenesis of GN and may help identify factors mediating more chronic subtypes of disease.
- Toward a Clearer Picture of IgA Nephropathy in Spondyloarthritis June 11, 2020No abstract
- Ask and It Shall Be Given: Patient-Centered Outcomes in Glomerular Diseases May 2, 2020No abstract
- Acute Kidney Injury Due to Collapsing Glomerulopathy Following COVID-19 Infection April 30, 2020No abstract
- How COVID-19 Has Changed the Management of Glomerular Diseases April 26, 2020No abstract
- Pilot Study of Return of Genetic Results to Patients in Adult Nephrology April 18, 2020CONCLUSIONS: Developing the infrastructure to support return of genetic results in nephrology was resource-intensive, but presented potential opportunities for improving patient care.