Andrew S. Bomback, MD, MPH (Co-Director)
Associate Professor of Medicine
Education & Training
- Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis July 1, 2022CONCLUSIONS: Our detailed assessment of kidney biopsy data indicated that cellular/fibrocellular crescents and interstitial fibrosis/tubular atrophy scores were significant determinants of deterioration in kidney function.
- Rituximab Is Preferable to Cyclophosphamide for Treatment of Membranous Nephropathy: PRO April 4, 2022No abstract
- Late Relapses of Membranous Nephropathy: A Case Series April 4, 2022CONCLUSIONS: This case series highlights a previously underappreciated, and likely rare, outcome of MN, namely, late relapse. Patients who experience late relapse, and who thus have a longer time in sustained remission, may have a more favorable long-term renal outcome.
- Conceptual framework for defining disease modification in systemic lupus erythematosus: a call for formal criteria March 29, 2022Disease modification has become a well-established concept in several therapeutic areas; however, no widely accepted definition of disease modification exists for SLE.We reviewed established definitions of disease modification in other conditions and identified a meaningful effect on 'disease manifestations' (ie, signs, symptoms and patient-reported outcomes) and on 'disease outcomes' (eg, long-term remission or progression of […]
- Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation March 27, 2022No abstract
- Use of ofatumumab and eplerenone in post-transplant recurrence of FSGS November 22, 2021CONCLUSIONS: With notable risk of recurrence of FSGS in kidney transplants leading to allograft failure, the use of ofatumumab and eplerenone in conjunction should be considered for management to induce remission.
- Noninvasive Diagnosis of PLA2R-Associated Membranous Nephropathy: A Validation Study November 16, 2021CONCLUSIONS: In patients with preserved eGFR and absence of associated conditions or diabetes, a positive anti-phospholipase A2 receptor test by either ELISA >20 RU/ml or a positive immunofluorescence assay confirms the diagnosis of membranous nephropathy, precluding the requirement for a kidney biopsy.
- Longitudinal Outcomes of COVID-19-Associated Collapsing Glomerulopathy and Other Podocytopathies October 21, 2021CONCLUSIONS: Half of 14 patients with COVID-19-associated collapsing glomerulopathy requiring dialysis achieved dialysis independence, but the long-term prognosis of residual proteinuric CKD remains guarded, indicating a need for more effective therapy.
- Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation September 27, 2021Blocking the complement system as a therapeutic strategy has been proposed for numerous glomerular diseases but presents myriad questions and challenges, not the least of which is demonstrating efficacy and safety. In light of these potential issues and because there are an increasing number of anticomplement therapy trials either planned or under way, the National […]
- Acute Hyponatremia After a Religious Fast July 26, 2021CONCLUSION: Clinicians should be cognizant that reproductive-age women are uniquely susceptible to hyponatremia and dangerous sequelae therein. They should counsel fasting individuals, particularly lactating women, to consume solute as well as fluid after fasting.
- Proposal for a more practical classification of antineutrophil cytoplasmic antibody-associated vasculitis July 5, 2021The nomenclature for antineutrophil cytoplasmic antibody (ANCA)-associated kidney disease has evolved from honorific eponyms to a descriptive-based classification scheme (Chapel Hill Consensus Conference 2012). Microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis do not correlate with presentation, response rates and relapse rates as when comparing myeloperoxidase versus leukocyte proteinase 3. Here we discuss […]
- De Novo and Relapsing Glomerular Diseases After COVID-19 Vaccination: What Do We Know So Far? June 28, 2021No abstract
- Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine May 17, 2021No abstract
- Urinary EGF and MCP-1 and risk of CKD after cardiac surgery May 11, 2021BACKGROUNDAssessment of chronic kidney disease (CKD) risk after acute kidney injury (AKI) is based on limited markers primarily reflecting glomerular function. We evaluated markers of cell integrity (EGF) and inflammation (monocyte chemoattractant protein-1, MCP-1) for predicting long-term kidney outcomes after cardiac surgery.METHODSWe measured EGF and MCP-1 in postoperative urine samples from 865 adults who underwent […]
- Glomerular Diseases in Diabetic Patients: Implications for Diagnosis and Management April 30, 2021The prevalence of diabetes continues to rise worldwide. In addition to rising rates of diabetic kidney disease, we are also seeing a parallel rise in nondiabetic kidney disease among patients with diabetes. These nondiabetic lesions include focal segmental glomerulosclerosis, IgA nephropathy, membranous nephropathy, and other glomerular diseases. The management of diabetic kidney disease is rapidly […]